1) include (1) impaired chromosome integrity due to increased DNA damage (e.g., DNA double-strand breaks) [21], (2) weakened chromosome cohesion during chromosome segregation, causing a decrease in the level of chromosomal adhesin subunits, making oocytes susceptible to premature sister chromatid segregation in homologous chromosomes [22, 23], (3) dysfunction of spindle assembly checkpoints, which interferes with chromosome segregation, leading to premature chromosome segregation and chromosome mislocalisation [24], (4) meiotic recombination errors [25], and (5) telomere shortening leading to impaired chromosome integrity [25]
Proc Natl Acad Sci USA 98 : 12551260
Liraglutide (Saxenda) is approved for weight management in adults and has also received FDA approval for adolescents aged 12 to 17 years with a body weight above 132 pounds (60 kg) and an initial BMI corresponding to 30 kg/m or greater in adults
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This is why the term "juvenile rheumatoid arthritis (JRA)" is no longer widely used and is known as juvenile idiopathic arthritis (JIA) instead
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