Aging is associated with functional and phenotypic alterations in the microcirculation, including endothelial dysfunction, oxidative stress, chronic low-grade inflammation, and microvascular rarefaction (reduced number and combined length of small vessels in a given volume of tissue)[289]
In the context of EMS, impaired mitophagy has significant pathological implications, resulting in the accumulation of dysfunctional mitochondria and elevated levels of ROS
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Author contributions CZ conceptualized and designed the study and critically reviewed and revised the manuscript
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