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NAD and GLP1: The Science Behind Synergy A pivotal study published in Endocrinology demonstrated that restoring intestinal NAD levels via supplementation improved GLP1 production and glucose metabolism in obese mouse models

Journal of Molecular Structure 1046 , 153163, doi:10.1016/j.molstruc.2013.04.043 (2013)

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The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite