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World J Surg Oncol

Dietary supplements are regulated by the FDA, but this only occurs after they have been brought to market, and not before

Rossing P, Filippatos G, Agarwal R, Anker SD, Pitt B, Ruilope LM, Chan JCN, Kooy A, McCafferty K, Schernthaner G, et al

Transient and mostly mild-to-moderate gastrointestinal symptoms were the most frequently reported AE and occurred more frequently with the 4 mg starting dose groups rather than the 2 mg starting dose groups [67]

Clinically, the importance of Ecust004 lies in its dual-targeting mechanism by serving both as a tubulin and steroid sulfatase inhibitor, which effectively induces G2/M cell cycle arrest and reverses EMT, a key driver of metastasis, by upregulating E-cadherin and downregulating transcription factors such as SLUG and ZEB1 (115)