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If you're using a strong retinoid or exfoliant, it's best to be cautious, as layering too many actives may cause irritation

Theor Exp Plant Physiol 30(1):1927 Amaglo NK, Bennett RN, Curto RBL et al (2010) Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana

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However, in the Diabetes Prevention Programme, which randomised 3,234 individuals with IGT to intensive lifestyle modification, metformin or placebo, there was no difference in the incidence of cardiovascular events between the treatment groups over 3 years [48]