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3.4 Endogenous TME-responsive release and activation Endogenous TME-responsive systems exploit biochemical gradients or pathological cues within tumor tissue to guide therapy-focused release or activation

Representative immunohistochemistry (b) and immunofluorescence (c) staining of indicated proteins in Gclc WT and Gclc KO mammary tumors (Scale bar = 50 m)

While the opioid receptor structures already provide detailed information about ligand-binding specificity, it remains to be determined how receptor activation is achieved

Sorkin A, von Zastrow M

Recheck at 12 weeks only if applying to large body surface areas (above 10% BSA), broken skin, or mucosal surfaces