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494 Lifestyle modification Lifestyle modification plays a pivotal role in the prevention and management of DN

The second drug currently on the market, the tirzepatide found in Mounjaro and Zepbound, resembles GLP-1 in addition to another hormone called GIP, hitting receptors for both in the brain

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Furthermore, current potential therapeutic strategies targeting inflammatory pathways are reviewed, including anti-inflammatory agents (e.g., cyclooxygenase-2 (COX-2) and NLRP3 inhibitors), antioxidants (such as N-acetylcysteine (NAC) and melatonin), probiotic modulation (via gut-brain axis (GBA) regulation), and precision therapies (such as mesenchymal stem cells (MSCs) and exosome-based approaches)

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