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While no one has investigated if muscle mass loss from Wegovy or Zepbound will worsen physical function among older adults with obesity, Ive had patients taking these medications say they felt weaker after losing large amounts of weight

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In this context, GLP-1RA drugs could activate the thermogenic proteins in brown adipocytes, increasing intracellular type 2 deiodinase (D2) expression and subsequent TH activation

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