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Abbreviations ESKD: End-stage kidney disease GLP-1 RA: Glucagon-like peptide-1 receptor agonist HF: Heart failure ICER: Incremental cost-effectiveness ratio MI: Myocardial infarction NDSS: National Diabetes Services Scheme QALY: Quality-adjusted life year SGLT2i: Sodiumglucose co-transporter 2 inhibitor References McGuire DK, Shih WJ, Cosentino F et al (2021) Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with type 2 diabetes: a meta-analysis

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Researchers typically start at 250 mcg once daily for the first two to three days to characterise nasal tolerability and response, then move to the target schedule

Other ingredients Sodium bicarbonate, sorbitol powder (E 420), saccharin sodium, sodium lauryl sulfate, citric acid, sodium carbonate, polyvinylpyrrolidone and silicone fluid