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Ania Jastreboff, a leading obesity researcher quoted in the piece, emphasized a critical principle for the high-dose era: We have to use the dose that the patient needs The underlying question is needing to approach and treat obesity as we would any other chronic disease. The challenge for providers is that there is no universal Goldilocks amount of weight loss

At week 52, the estimated median ratio to baseline in maximum walking distance was 1.21 in the semaglutide group compared to 1.08 in the placebo group

Substantial contributions to the conception or design of the work

Off-label means that a drug is prescribed for a purpose other than its intended indication

LUPKIN: Novo Nordisk may have a bit of an edge here