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Meanwhile, pharmaceutical companies depend on a system that rewards the enormous investment required to develop FDA-approved medicines otherwise they wont spend the money to develop ground breaking drugs like GLP-1s in the first place

10.1038/ng1001-160 380 YangM.LiangC.SwaminathanK.HerrlingerS.LaiF.ShiekhattarR.et al

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

High levels of fumarate accumulate and act as oncometabolites, which often result in dysregulation of cellular functions in SDH- or FH-deficient cells [1]

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