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Both medications share similar GI side effects like nausea and constipation, but tirzepatide's dual-pathway action sometimes causes more intense initial effects because it stimulates two receptor types simultaneously

During the 40- to 104-week treatment periods with ADA sampling conducted up to 44 to 108 weeks in seven clinical trials in adults with type 2 diabetes mellitus [see Clinical Studies (14)], 51% (2,570/5,025) of MOUNJARO-treated patients developed anti-tirzepatide antibodies

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