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The health technology assessment framework established for Japan in 2019 recommends costutility analysis, with calculation of incremental cost-effectiveness ratios based on direct costs and quality-adjusted life expectancy [12]

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According to the EMAs Pharmacovigilance Risk Assessment Committee, NAION will be listed as a rare side effect, meaning it may occur in up to 1 in 10,000 patients after a year or more of treatment

The fundamental mechanism of TRZ in weight reduction is related to the dual activation of GIP and GLP-1 receptors