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Liang, Q

(See Holford et al, 2013, for parameters in neonates and children.) Knowing the relationship between dose, drug concentration, and effects allows the clinician to take into account the various pathologic and physiologic features of a particular patient that make him or her different from the average individual in responding to a drug

This titration minimizes disruptions to the bodys equilibrium

Figure 4 Macrocyclic Angiotensin IV Analogues The capability of IRAP to degrade physiologically important cyclic peptides has inspired the development of macrocyclic analogues of Ang IV

Abbreviations BMI, body mass index