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The mechanism of action involves several key effects: Enhanced insulin secretion : GLP-1 medications stimulate the pancreas to release insulin in a glucose-dependent manner, meaning they work primarily when blood glucose levels are elevated

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Mutant p53 inhibits autophagy by decreasing the mRNA or protein levels of Sestrins, preventing the activation of the AMPK signaling pathway and the formation of autophagic vesicles

Dulbeccos modified Eagles medium/F12 and fetal bovine serum were purchased from Gibco (Logan, UT, USA)