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[12] Clinical manifestations, such as low blood pressure, and low-grade fevers, and dark circles around the eyes, may occur

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Suffers of the serious genetic condition phenylketonuria (PKU) are unable to convert phenylalanine to tyrosine, whilst patients with alkaptonuria have a defective tyrosine metabolism, producing distinctive urine which darkens when exposed to the air

doi: 10.1038/s41385-020-00357-4 153 MekonnenSAMerensteinDFraserCMMarcoML