These studies investigate various mechanisms, including altered energy metabolism (e.g., glycolysis and oxidative phosphorylation), lysosomal dysfunction, RNA toxicity, and mtDNA mutations
Within this framework, defining evidence-based priorities for future research becomes critical to translate these complementary strategies into clinically meaningful outcomes
cGAS-STING signaling in astrocytes and CNS inflammation In astrocytes, AD model mice (5xFAD) crossed with the Cgas / line exhibited a reduction in GFAP + cell area, indicating the involvement of the cGAS-STING pathway (Xie et al., 2023)
oleifera have shown anti-cancer activity by preventing cancer cell proliferation (85)
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