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Excitotoxicity may occur when, for instance, extracellular glutamate accumulates due to impaired uptake by astrocytes or excessive synaptic release
Gastrointestinal tolerability may be challenging, as both ketogenic diets and GLP-1 agonists can cause nausea, constipation, and altered bowel habits
Furthermore, there is a direct link between high NGAL levels and albuminuria in people with chronic kidney disease, and NGAL as a biomarker for AKI has been extensively studied
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