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Brooks, [email protected] Specialty section: This article was submitted to Molecular and Structural Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Introduction A considerable proportion of people who live in plains will suffer from high-altitude illnesses when they suddenly ascend to an altitude of over 2,500 m without acclimatization, such as acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE