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B12 deficiency upregulates lipogenesis in mature human WAT To validate the evidence of low B12 effect on lipogenesis in the Chub-S7 cells and primary Sc adipocytes, gene expression was further investigated in ScWAT and OmWAT derived from pregnant women with sufficient and deficient levels of B12

Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH

Epub 2013 Feb 27

With obesity, levels of MCP-1 and TNF- increase in VAT before macrophage infiltration, suggesting a highly proinflammatory phenotype of the visceral depot prior to infiltration of immune cells and macrophage phenotype switch [77]