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When to seek medical advice: Persistent or worsening injection site reactions (increasing redness, warmth, or discharge suggesting infection) Severe or persistent headaches Chest pain or palpitations Unexplained muscle weakness or cramps New or worsening neurological symptoms despite treatment Unexpected bleeding or bruising For non-emergency concerns, contact your GP or NHS 111

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Readers should weigh the comparator choices (the paper compares the conjugate favorably against semaglutide, a Novo product, and against a tirzepatide-equivalent backbone, a Lilly product) in light of these affiliations

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