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If the injection is given IV (slowly), there may be a brief sensation of warmth or a mild flushing during the infusion, owing to the niacinamide component

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In the case of water-soluble vitamins like B12, vitamin C, folic acid, and other B vitamins, some medically reviewed literature points to early morning as the optimal time to take them as they can be taken on an empty stomach, but more peer-reviewed research is needed to confirm this claim

Essential for red-blood-cell production deficiency causes anaemia

Vitamin B12 plays a role in DNA synthesis and red blood cell formation