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If a person refuses treatment at first, its important for their loved ones to continue to express their concerns in a kind and respectful manner, and to periodically encourage them to get help

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Additionally, metformin upregulates nuclear respiratory factors like Nrf2, reducing the oxidative stress

Week 9 onward: 0.5 mg weekly can be maintained, or if additional blood sugar lowering is needed, increase to 1 mg weekly after at least 4 weeks on 0.5 mg

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