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Compounded formulations often cost significantly less than brand-name versions, making longer treatment courses more financially feasible for many patients

Metabolic adaptation reduces energy expenditure as body weight decreases, whilst hormonal changes in leptin, ghrelin, and thyroid hormones influence appetite and energy balance

However, they work slightly differently

It is possible that optimizing dose escalation schedules will improve tolerability, and this should be further explored in future studies (20)

Rates of acute pancreatitis, cholecystitis, and cholecystectomy were similar between GLP-1 RA users and the control group