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The 7.2 mg dose was approved to help patients achieve deeper weight reductionproducing nearly 20% total weight loss in the STEP UP clinical trialsputting its efficacy much closer to that of tirzepatide

From a translational perspective, combining GLP-1RAs with interventions that selectively increase vagal afferentNTS signaling represents a promising approach

Although GLP-1 receptors in the retina, ganglion cells and central nervous system play a neuroprotective role by suppressing neuroinflammationsuggesting no direct causalitythe rapid normalization of glycemic control and weight loss may disrupt pre-existing vascular stability, potentially increasing the risk of NAION, they wrote

For many patients, this can translate into easier training, steadier energy, and better recovery when combined with healthy habits