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The neuroprotective effect of GLP-1R agonists is that it can either directly/locally cause neuroprotection by acting on neuronal tissue or indirectly/systemically cause neuroprotection by improving glycemic control and treating existing insulin resistance (Figure 3) ( FIGURE 3 Alzheimers Disease Several early studies have identified the presence of cognitive impairment in patients with T2D (Perlmuter et al., 1984