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Copper can diffuse out of the synapse driven by the lower extrasynaptic concentration (1 M ) [216]

The estimated lifetime prevalence of binge eating disorder and bulimia nervosa worldwide is 1.9% and 1%, respectively

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Atherogenic and visceral-obesity indices have been conceded as surrogate cardiovascular diseases (CVD) indicators surpassing the conventional markers due to stronger predictive power for obesity-induced cardiometabolic risk and CVD mortality rate

113,114,115,116 Activation of these receptors initiates an inflammatory signaling cascade resulting in the secretion of pro-inflammatory cytokines and chemokines