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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes
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Human studies were prioritised, while preclinical studies were included when they provided mechanistic evidence relevant to taste signalling, brainstem integration, interoception, or food-reward pathways