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Consequently, GPX4 (both mitochondrial and cytoplasmic isoforms) loses its capacity to reduce lipid hydroperoxides

Nanomedicine and gene therapy represent another frontier of IDD treatment, with potential advancements in mitochondria-targeted nanoparticle design, such as TAT-PEG-MitoQ, to enhance drug delivery efficiency while reducing systemic toxicity

For example, a bile acid metabolite (gut microbiome-derived glycochenodeoxycholic acid) activates the TFR/ACSL4 pathway to induce ferroptosis, promoting progression of environmental toxin-associated metabolic dysfunction-associated fatty liver disease (Liu et al., 2022a)

Lyophilization (freeze-drying) is often used for long-term storage, preserving integrity and stability by removing water under low pressure