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DON, which exhibits high structural similarity to Gln, enhances the cytotoxic effects of CD8+ T cells while inhibiting Gln metabolism in cancer cells

doi: 10.1016/j.braindev.2020.04.002 84

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The resultant oxidative stress adversely impacts cochlear homocysteine metabolism, suggesting a potential link between Vitamin B12 deficiency and demyelination of neurons in the cochlear nerve, axonal degeneration, and neuronal death