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Visual Format: Approved vs investigational status map Key Labels: Cosmetic product, compounded peptide, non-injectable route, injectable route, FDA safety concern, approved drug label, regulatory standards, product category Suggested Layout: Use a horizontal status map with four blocks: Cosmetic context, Non-injectable compounding review, Injectable safety concern, and Approved drug labeling. Add a note that product category changes evidence and safety interpretation

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A 2021 study in JAMA Internal Medicine found that menopausal transition was independently associated with a 1.2 kg per year increase in visceral fat, even after controlling for age and physical activity