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accordingly, the absence of a stable teratogenic pattern should not be interpreted as proof of safety ( From a practical standpoint, the most defensible position remains planned exposure avoidance: explicit fertility planning, reliable contraception during treatment, label-informed discontinuation before conception attempts, immediate cessation once pregnancy is recognized, and active metabolic maintenance during the washout period to reduce rebound-related gestational risk ( 4.5.1 Post-discontinuation weight rebound and gestational risk Evidence for post-discontinuation weight rebound and related gestational risk is derived predominantly from non-PCOS or mixed-population cohorts rather than from PCOS-specific longitudinal studies