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In pathological conditions, such as obesity and diabetes, the EAT brown fat-like activity decreases substantially and the proportion of brown adipocytes decreases in favor of white adipocytes [35], promoting inflammation with all the well-known inflammatory consequences and deleterious metabolic effects [62,63,64,65,66]

Nature Reviews Immunology, 5, 1-15

Experts say managing weight is hard

Medicare does not cover FDA-approved weight-management drugs for weight alone as of April 2026, though some products carry cardiovascular-indication coverage