Victoza for diabetes (up to 1.8 mg), Saxenda for weight management (up to 3 mg) Oral GLP-1 option : Semaglutide (Rybelsus) is the only oral GLP-1 receptor agonist, taken once daily on an empty stomach with specific administration requirements: take with no more than 4 ounces of plain water, at least 30 minutes before eating, drinking, or taking other oral medications, and swallow tablets whole without breaking or chewing
Every clinical trial from the STEP program to the SUSTAIN trials evaluated the drug on a weekly injection schedule
As GLP-1driven weight loss scales across populations, the accompanying loss of muscle becomes a strategic vulnerability
GLP-1 RA vs DPP-4i HR 0.81 (0.750.88), 3.8 vs 4.7/1,000 ( 0.9
Regulatory note: Injectable/IV NAD+ is not FDA-approved (or approved by any major regulator) for energy, metabolic or longevity uses