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Images of slides were acquired using a Leica TCS SP8 scanning confocal microscopy system with a Plan Apo 60 objective (Leica Microsystems, Mannheim, Germany)

This means that drawing the same number of units from a 20mg/mL vial delivers double the dose compared to a 10mg/mL vial

Zhangs study demonstrated that the synthesis of GSH is intricately linked to serine metabolism, with its metabolic byproducts lactate and 2-hydroxyglutarate (2-HG) suppressing the cytotoxic function of T cells

Conversely, if glutathione production process (or the trans-sulfuration pathway) is not functioning properly, the process backs up and homocysteine levels accumulate putting additional strain on the methylation cycle to remove it

The disorder of 5-oxoprolinemia should be considered in patients with unexplained HAGMA