Topical NSAIDs , such as ibuprofen gel or diclofenac gel, can be effective for localised musculoskeletal pain (e.g., knee osteoarthritis, soft tissue injuries) whilst minimising systemic exposure and gastrointestinal side effects
By aligning key protocol components and analytic frameworks with those of SUSTAIN-6 and SURPASS-CVOT, we produced self-critical evidence that allowed us to directly benchmark results against reference trials to inform subsequent analyses in expanded populations
Key Findings Over the course of 64 weeks, participants receiving oral semaglutide lost an average of 13.6 percent of their baseline body weight, compared with 2.2 percent in the placebo group
From there, tirzepatide is gradually increased over time based on individual tolerability
Case reports published in PMC have documented semaglutide-induced gastroparesis, particularly in patients with pre-existing risk factors or those who escalated doses too rapidly