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Under the influence of a leaky epithelial barrier, the immune system is locally activated and inflammation develops, which can be transmitted via immune cells and the cytokines they secrete to other systems and organs

These results suggested that r-sFNDC5 possesses anti-obesity activity, similar to irisin (Xiong et al., 2015), and more importantly, these secreted FNDC5 derivatives may mediate the lipolysis effects of GLP-1 on adipose tissue