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Transcellular and Intercellular Pathways: The active ingredient can travel through the skin cells (transcellular) or between the cells (intercellular)

By moderately promoting oxidative stress, the antioxidant defense mechanisms of vascular endothelial cells can be activated, reducing the formation of oxidized LDL and thus alleviating the progression of atherosclerosis [197]

The relative abundance of lipids were determined from normalized response with respect to internal standards, calculated using area under the curve of the extracted chromatogram for individual lipids

The means of the calculated species-specific standard redox potentials are listed in Table 2

Qiao J, Chen L, Huang X, Guo F