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Trigonelline in minimizing oxidative stress Moreover, trigonelline was found to minimize oxidative stress by boosting antioxidant enzyme activity and have a scavenging effect on ROS in a study conducted on rats (Zhou et al., 2013)

CYP11A1 by PCR overexpression could not downregulate CYP19A1( Figure 4B and Figure S4A ) and WB ( Figure 4D and Figure S4C )

Further mechanistic studies in TgSwDI mice indicate that OC also activates the ApoE-dependent amyloid clearance pathway and increases A-degrading enzymes, allowing a multifaceted reduction in cerebral amyloid burden (80)

10.1016/j.bbagen.2012.10.012 Biochim