Pre-existing risk factors include: Men and those over 40 (though post-menopausal women also face increased risk) Family history of gout or hyperuricaemia Obesity itself , which is associated with higher uric acid production Metabolic syndrome , including hypertension, dyslipidaemia, and insulin resistance Chronic kidney disease , which impairs uric acid excretion Certain medications , such as diuretics (particularly thiazides), low-dose aspirin, and ciclosporin Dietary factors that may interact with weight loss treatment include: High intake of purine-rich foods (red meat, organ meats, certain seafood) Excessive alcohol consumption, particularly beer and spirits High-fructose beverages and foods Dehydration or inadequate fluid intake Weight loss-specific considerations are particularly relevant for Saxenda users
10.3390/nu6126020 Nutrients 22 ArakiT.SasakiY.MilbrandtT
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Overall, when used appropriately with attention to nutrition and physical activity, semaglutide does not "ruin" metabolism but rather can improve multiple metabolic parameters while supporting clinically meaningful weight loss in appropriate patients
Furthermore, it is contraindicated in dialysis patients due to the potential increase in TMAO production