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Although it does not have any carcinogenic and teratogenic effects, it is not recommended for use during pregnancy and lactation periods due to lack of sufficient evidence

For instance, for inflammatory pathways, blocking the expression of G6PD impaired pro-inflammatory cytokine expression and lipid accumulation in LPS-activated DCs ( de novo lipid synthesis, the loss of G6PD function also led to impaired NOS2 activity in Ms activated by LPS (61) or by IFN- and infected by Trypanosoma cruzi (62)

Women with PCOS are inclined to incur a higher chance of type 2 diabetes aside from the ones caused by cardiovascular disease because of the application of high-carbohydrate diets, which exacerbate insulin resistance

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Van Gilst, M