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In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]
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Despite this large disease burden, uptake of GLP-1 therapies remains limited
Acquiring healthy CSF control samples can be challenging, but potential sources include commercial providers and patients with various alternative disorders or those undergoing specific medical procedures, who can serve as suitable controls for research purposes
Similarly, batch-specific documentation may be hard to trace
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