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--- 7 Contraindications / Cautions Sick sinus syndrome Bradycardia Peptic ulcer disease Asthma/COPD Concomitant anticholinergic drugs (reduce effect) --- 8 Drug Interactions Anticholinergics Oppose action CYP3A4 inhibitors (e.g., ketoconazole) levels CYP inducers (e.g., rifampicin) levels Beta-blockers risk of bradycardia --- 9 Comparison With Other Drugs Drug Selectivity Half-life Notes Donepezil CNS selective Long Once daily Rivastigmine Less selective Shorter Patch available Galantamine Moderate Moderate Also enhances nicotinic receptors --- Clinical Pearls Best tolerated among cholinesterase inhibitors No titration beyond recommended schedule Improvement seen in 46 weeks Stop if no clinical benefit To view or add a comment, sign in Overview of the common classes of antihypertensive drugs, their mechanisms, examples 1

Clinical trials such as the STEP programme have examined body composition changes with treatment

The detailed testing and medical consultation process identifies potential risks specific to your health history

It has demonstrated low skin irritability when applied topically, both with and without microneedle-assisted delivery

It also helps to rebuild the collagen an elastin in your skin which results in tightening and elimination of any sagging