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There are several reports that have delineated the mutations in these co-activator genes as the major force driving disease progression

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This gender distribution matters because it means we have robust data specifically for female outcomes rather than extrapolating from male-dominated studies

The certainty of evidence, assessed using GRADE methodology, ranged from high for colorectal cancer to moderate for liver cancer to low for pancreatic cancer, reflecting variations in trial consistency and event rates (Pieber et al., 2019