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Metabolic reprogramming further exacerbates immunosuppression, such as the conversion of extracellular ATP to adenosine mediated by the CD39/CD73 axis, which not only inhibits CTL function but also promotes T cell exhaustion by activating the adenosine A2A receptor (ADORA2A) (207)
Zinc supplementation increases resistance to experimental infection by Trypanosoma cruzi
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A meta-analysis highlighted the effect of statins in significantly reducing hepatic biochemical markers in MASLD 38 and their association with a lower risk of hepatocellular carcinoma 39
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