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In some individuals, significant alterations in these neuroendocrine pathways may negatively affect functional outcomes, cognition, and emotions

thus the ion channel remains closed and unresponsive to incoming depolarizing currents (Figure 21-4)

Semin Oncol 30(1 Suppl 1):2129 Lu YP, Lou YR, Lin Y, Shih WJ, Huang MT, Yang CS, Conney AH (2001) Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat