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Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

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The importance of mitochondrial glutathione extends to neurological health, as neurons are particularly vulnerable to oxidative damage due to their high metabolic demand and limited regenerative capacity

MC1R is a G-protein-coupled receptor (GPCR) that, upon agonist engagement, activates the Gs/adenylate cyclase pathway, increasing intracellular cAMP and activating PKA-linked signalling cascades that upregulate tyrosinase activity and drive eumelanin synthesis the dark, UV-protective form of melanin