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Agonists of Nuclear Factor Erythroid 2-Related Factor 2 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that interacts with Keap1 and is ubiquitinated by Cullin 3 in the cytoplasm prior to its degradation in the proteasome
[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Warner M.A., Meyerhoff K.L., Warner M.E., Posner K.L., Stephens L., Domino K.B
By targeting the stubborn, pro-inflammatory senescent cells that accumulate with age, FOXO4-DRI offers the possibility of clearing the cellular garbage that impedes regeneration, contributes to chronic disease and ageing decline