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Abbreviations ACE: Angiotensin-converting enzyme DPP-IV: Dipeptidyl peptidase IV X-Hyp: X-hydroxyproline X-Hyp-Gly: X-hydroxyproline-glycine Gly-X-Y: Glycine-XY Pro: Proline Hyp: Hydroxyproline Tyr: Tyrosine Trp: Tryptophan Phe: Phenylalanine His: Histidine Met: Methionine Glu: Glutamine Hyp: Hydroxyproline ROS: Reactive oxygen species SOD: Superoxide dismutase CAT: Catalase GSH: Glutathione Zn 2 : Zinc ion Val: Valine GIP: Glucose-dependent insulinotropic peptide GLP-1: Glucagon peptide-1 T2DM: Type 2 diabetes GPCRs: G-protein coupled receptors Ser: Serine References Granato D, Barba FJ, Bursa Kovaevi D, Lorenzo JM, Cruz AG, Putnik P

By cleverly combining response mechanisms to external stimuli (temperature, magnetic field, light) and internal stimuli (specific biomolecules, pH changes, redox potential), these nanoparticles can achieve intelligent drug release in complex and variable biological environments, thereby maximizing the therapeutic value of drugs during the treatment process [126]

doi:10.1161/CIRCULATIONAHA

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