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Ethics declarations Ethics approval and consent to participate The animal study was performed according to the institutional animal care and use committee of the First Affiliated Hospital, Zhejiang University School of Medicine and approved (2023 702) by the Tab of Animal Experimental Ethical Inspection of the First Affiliated Hospital, Zhejiang University School of Medicine (date of approval: February 22, 2023)

Dosage & Administration: Administered intramuscularly or intravenously as directed by a healthcare professional

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CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life

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